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For these reasons, nude mice are less popular in research today. In addition, knockout mice with more complete defects in the immune system have been constructed (e.g. Most strains of nude mice are slightly "leaky" and do have a few T cells, especially as they age. Moreover, the absence of functioning T cells prevents nude mice from rejecting not only allografts (grafts of tissue from other mice) but also xenografts (grafts of tissue from another species). graft rejection (requires both CD4+ and CD8+ T cells)īecause of the above features, nude mice have served in the laboratory to gain insights into the immune system, leukemia, solid tumors, AIDS and other forms of immune deficiency as well as leprosy.killing of virus-infected or malignant cells (requires CD8+ cytotoxic T cells).
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The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. Lab mouse strain lacking immunity and fur A nude mouseĪ nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells.